Trypanosomes show their commitment

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Trypanosomes show their commitment

Pek et al. describe how a stable, intron-derived RNA regulates the expression of its host gene during Drosophila embryogenesis. Once they are spliced out of nascent mRNAs, noncoding intron sequences are usually degraded rapidly. At least in Xenopus eggs and human cell lines, however, some intronic RNAs persist for long periods, although the function of these stable intronic sequence (sis) RNAs ...

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Commitment to differentiation and cell cycle re-entry are coincident but separable events in the transformation of African trypanosomes from their bloodstream to their insect form.

African trypanosomes undergo extensive changes in cellular morphology, biochemistry and surface antigen expression as they differentiate from their bloodstream form to those forms that colonise the midgut of their tsetse fly vector. If initiated with stumpy-form cells, a non-dividing sub-type of the bloodstream parasite, differentiation and cell cycle re-entry occur synchronously in the populat...

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Physically Active Men Show Better Semen Parameters than Their Sedentary Counterparts

Objective The quality of semen depends upon several factors such as environment, life style, physical activity, age and occupation. The aim of this study was to analyze and compare the conventional and functional semen parameters in men who practice vigorous physical activity to those of sedentary men. MaterialsAndMethods Semen samples from 17 physically active men and 15 sedentary men were col...

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Trapdoor commitment schemes and their applications

Look, matey, I know a dead parrot when I see one, and I'm looking at one right now. Preface There are certainly one or two things about cryptography I have learned during my Ph.D. time. One thing I have noticed is that trapdoor commitments are a remarkable catalyst for the design of provably secure cryptographic protocols. Introduction Informally, commitment schemes can be described by lockable...

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Duchenne Muscular Dystrophy Models Show Their Age

The lack of appropriate animal models has hampered efforts to develop therapies for Duchenne muscular dystrophy (DMD). A new mouse model lacking both dystrophin and telomerase (Sacco et al., 2010) closely mimics the pathological progression of human DMD and shows that muscle stem cell activity is a key determinant of disease severity.

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ژورنال

عنوان ژورنال: Journal of Cell Biology

سال: 2015

ISSN: 1540-8140,0021-9525

DOI: 10.1083/jcb.2112iti3